SARS: clinical features and diagnosis
Identifieur interne : 006199 ( Main/Exploration ); précédent : 006198; suivant : 006200SARS: clinical features and diagnosis
Auteurs : David Shu-Cheong Hui [Hong Kong] ; Poon-Chuen Wong ; Chen Wang [République populaire de Chine]Source :
- Respirology [ 1323-7799 ] ; 2003-11.
Descripteurs français
- KwdFr :
- Guides de bonnes pratiques cliniques comme sujet, Humains, Organisation mondiale de la santé, Radiographie, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (imagerie diagnostique), Virus du SRAS (isolement et purification), États-Unis d'Amérique, Évolution de la maladie.
- MESH :
- diagnostic : Syndrome respiratoire aigu sévère.
- imagerie diagnostique : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- Guides de bonnes pratiques cliniques comme sujet, Humains, Organisation mondiale de la santé, Radiographie, Syndrome respiratoire aigu sévère, États-Unis d'Amérique, Évolution de la maladie.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Centers for Disease Control and Prevention, U.S., Disease Progression, Humans, Practice Guidelines as Topic, Radiography, SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (diagnostic imaging), United States, World Health Organization.
- MESH :
- geographic : United States.
- complications : Severe Acute Respiratory Syndrome.
- diagnosis : Severe Acute Respiratory Syndrome.
- diagnostic imaging : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- Centers for Disease Control and Prevention, U.S., Disease Progression, Humans, Practice Guidelines as Topic, Radiography, World Health Organization.
Abstract
Severe acute respiratory syndrome (SARS) is a highly infectious disease with a significant morbidity and case fatality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache and dyspnoea. Less common symptoms include sputum production, sore throat, coryza, dizziness, nausea, vomiting and diarrhoea. Older subjects may present with decrease in general well‐being, poor feeding, fall/fracture and delirium, without the typical febrile response. Common laboratory features include lymphopenia with depletion of CD4 and CD8 lymphocytes, thrombocytopenia, prolonged activated partial thromboplastin time, elevated D‐Dimer, elevated alanine transminases, lactate dehydrogenase and creatinine kinase. The constellation of compatible clinical and laboratory findings, together with the rather characteristic radiological features especially on HRCT and the lack of clinical response to broad‐spectrum antibiotics, should quickly arouse suspicion of SARS. The positivity rates of urine, nasophargyngeal aspirate and stool specimen have been reported to be 42%, 68% and 97%, respectively, on day 14 of illness, whereas serology for confirmation may take 28 days to reach a detection rate above 90%. Recently, quantitative measurement of blood SARS CoV RNA with real‐time RT‐PCR technique has been developed with a detection rate of 80% as early as day 1 of hospital admission but the detection rates drop to 75% and 42% on day 7 and day 14, respectively.
Url:
- https://api.istex.fr/ark:/67375/WNG-NB5JB9X1-5/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169175
DOI: 10.1046/j.1440-1843.2003.00520.x
Affiliations:
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Le document en format XML
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type="ISSN">1323-7799</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Centers for Disease Control and Prevention, U.S.</term><term>Disease Progression</term><term>Humans</term><term>Practice Guidelines as Topic</term><term>Radiography</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (complications)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (diagnostic imaging)</term><term>United States</term><term>World Health Organization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Organisation mondiale de la santé</term><term>Radiographie</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (imagerie diagnostique)</term><term>Virus du SRAS 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xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Centers for Disease Control and Prevention, U.S.</term><term>Disease Progression</term><term>Humans</term><term>Practice Guidelines as Topic</term><term>Radiography</term><term>World Health Organization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Organisation mondiale de la santé</term><term>Radiographie</term><term>Syndrome respiratoire aigu sévère</term><term>États-Unis d'Amérique</term><term>Évolution de la maladie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a highly infectious disease with a significant morbidity and case fatality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache and dyspnoea. Less common symptoms include sputum production, sore throat, coryza, dizziness, nausea, vomiting and diarrhoea. Older subjects may present with decrease in general well‐being, poor feeding, fall/fracture and delirium, without the typical febrile response. Common laboratory features include lymphopenia with depletion of CD4 and CD8 lymphocytes, thrombocytopenia, prolonged activated partial thromboplastin time, elevated D‐Dimer, elevated alanine transminases, lactate dehydrogenase and creatinine kinase. The constellation of compatible clinical and laboratory findings, together with the rather characteristic radiological features especially on HRCT and the lack of clinical response to broad‐spectrum antibiotics, should quickly arouse suspicion of SARS. The positivity rates of urine, nasophargyngeal aspirate and stool specimen have been reported to be 42%, 68% and 97%, respectively, on day 14 of illness, whereas serology for confirmation may take 28 days to reach a detection rate above 90%. Recently, quantitative measurement of blood SARS CoV RNA with real‐time RT‐PCR technique has been developed with a detection rate of 80% as early as day 1 of hospital admission but the detection rates drop to 75% and 42% on day 7 and day 14, respectively.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Wong, Poon Huen" sort="Wong, Poon Huen" uniqKey="Wong P" first="Poon-Chuen" last="Wong">Poon-Chuen Wong</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Hui, David Shu Heong" sort="Hui, David Shu Heong" uniqKey="Hui D" first="David Shu-Cheong" last="Hui">David Shu-Cheong Hui</name></noRegion><name sortKey="Hui, David Shu Heong" sort="Hui, David Shu Heong" uniqKey="Hui D" first="David Shu-Cheong" last="Hui">David Shu-Cheong Hui</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Chen" sort="Wang, Chen" uniqKey="Wang C" first="Chen" last="Wang">Chen Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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